Prostatic Acid Phosphatase Measurement Its Role in the Detection and Management of Prostatic Cancer (Annals of the New York Academy of Sciences)

Cover of: Prostatic Acid Phosphatase Measurement |

Published by New York Academy of Sciences .

Written in English

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Subjects:

  • Oncology,
  • Physiology,
  • Urology & urogenital medicine,
  • Diagnosis,
  • Prostatic neoplasms,
  • Prostate,
  • Cancer,
  • Acid phosphates

Edition Notes

Book details

ContributionsLeslie M. Shaw (Editor), Nicholas A. Romas (Editor), Herman J. Cohen (Editor)
The Physical Object
FormatHardcover
Number of Pages147
ID Numbers
Open LibraryOL8267110M
ISBN 100897661702
ISBN 109780897661706

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Prostatic Acid Phosphatase Measurement book. Read reviews from world’s largest community for : Osteoclasts contain an isoenzyme of acid phosphatase that can be distinguished from prostatic acid phosphatase because it is tartrate resistant (type 5 tartrate-resistant acid phosphatase [TRAP5]).

The measurement of total TRAP activity in serum has been used as an index of osteoclast activity. Acid phosphatases (APs) are a family of enzymes that are widespread in nature, and can be found in many animal and plant species. Measurement of serum TRAP has yet to achieve the clinical acceptance associated with other established markers of bone resorption.

78, 79 However, Prognostic role of serum prostatic acid phosphatase for Pd. Serum Tartrate-Resistant Acid Phosphatase.

Osteoclasts contain an isoenzyme of acid phosphatase that can be distinguished from prostatic acid phosphatase because it is tartrate resistant (type 5 tartrate-resistant acid phosphatase [TRAP5]).

The measurement of total TRAP activity in serum has been used as an index of osteoclast activity. Comparison of prostatic and nonprostatic acid phosphatase / Kwok-Wai Lam [and others] --Characteriazation of antigenic sites of human prostatic acid phosphatase / B.K.

Choe [and others] --Human prostatic acid phosphatase: a histidine phosphatase / Robert L. Van Etten --Immunochemcial characterization of prostatic acid phosphatase with.

HUMAN PAP. Human PAP, also known as Acpp or prostatic specific acid phosphatase (PSAP), is a secreted glycoprotein ( kDa) enzyme (E.C.

) that is synthesized in the prostate gland’s epithelial cells (Vihko et al., ).Although used as a prostate cancer marker and studied widely in the past few decades, its physiological role is not clearly understood by: Prostatic acid phosphatase needs to be differentiated from the non-prostatic sources like RBCs source.

Total AP = AP after tartarate inhibition = Prostatic AP. Normal. Total acid phosphatase to ng /mL or to µg/L. or less than mg Prostatic Acid Phosphatase Measurement book.

Prostatic acid phosphatase =. Acid Phosphatase, Prostatic Synonym/acronym: Prostatic acid phosphatase, o-phosphoric monoester phosphohydrolase, PAcP PAP.

Common use To assist in staging prostate cancer and document evidence of sexual intercourse through semen identification in alleged cases of rape and sexual abuse. Specimen Serum (1 mL) collected in a red-top tube.

A swab with. Cautions. Prostatic acid phosphatase (PAP) measurement must not be regarded as an absolute test for malignancy since other factors, including benign prostatic hyperplasia, prostatic infarction, and manipulation of the prostate gland may result in elevated serum PAP concentrations.

Prostatic Acid Phosphatase Blood Test. This test measures Prostatic Acid Phosphatase (PAP) in a blood sample.

Prostatic Acid Phosphatase is a glycoprotein produced by the prostate gland. PAP testing is typically done to monitor people being treated for Prostate Cancer. Prostatic acid phosphatase (PAP, EC ) is a specific acid phosphatase derived from the prostate gland.

In normal males a small but detectable level of this enzyme is present in serum. When PAP was found to be elevated in the serum of patients with prostatic cancer [2, 3, 14, 17], the measurement of this enzyme became an accepted clinical Cited by: 6.

Acid Phosphatase, Prostatic Synonym/acronym: Prostatic acid phosphatase, o -phosphoric monoester phosphohydrolase, PAcP PAP. Common use To assist in staging prostate cancer and document evidence of sexual intercourse through semen identification in alleged cases of rape and sexual abuse.

Specimen Serum (1 mL) collected in a red-top tube. Prostatic acid phosphatase (PAP), a glycoprotein synthesized by the prostate gland, is a member of a diverse group of isoenzymes, the acid phosphatases, Prostatic Acid Phosphatase Measurement book are capable of hydrolyzing phosphate esters in acidic medium.

They are classified on the basis of their electrophoretic mobilities. PAP stands for prostatic acid phosphatase and if your result was 3 or under that is a good thing (according to Dr.

Steven Strum). Rather than try to explain it here, just google PAP and prostatic acid phosphatase, which will give you a better understanding of it than if I tried to explain it. Steven Strum discusses the importance of this test in his book on PCa, which I recommend (a bit. Objective. To characterize the disease progression and median survival of patients with prostate cancer (PCa) according to the prostatic-specific acid phosphatase (PAP) analysis in a population-based study from the Surveillance, Epidemiology, and End Results (SEER) database.

Materials and Methods. Prostate cancer patients with completed PAP results were identified using the SEER database of Cited by: 1. Prostatic Acid Phosphatase (PAP) test is a type of blood test to determine health of prostate gland by measuring prostatic acid phosphatase levels. PAP is an enzyme found in men and majorly present in the prostate gland and semen.

Significant amounts of PAP are also found in. Prostatic acid phosphatase is a glycoprotein which is synthesized by the prostate gland. The acid phosphatase is a membrane of a diverse group of isoenzymes which are capable of hydrolyzing phosphate esters in acid medium.

Prostatic acid phosphatase test is. Prostatic adenocarcinoma and duct carcinoma (considered more sensitive but less specific than PSA) PSA / PAP less sensitive in poorly differentiated adenocarcinoma (Am J Surg Pathol ;, Am J Surg Pathol ;) PSA / PAP may become negative after hormonal treatment (Hum Pathol ;) Bladder adenocarcinomas and rectal carcinomas may be strongly PAP+.

The acid phosphatase is a membrane of a diverse group of isoenzymes which are capable of hydrolyzing phosphate esters in acid medium. Prostatic acid phosphatase test is clinically useful prognostic information for predicting recurrence in men who are undergoing.

Since the first demonstration of elevation of serum acid phosphatase in advanced prostatic cancer by Gutman and his associates, measurement of this enzyme has been employed as a biochemical aid to diagnosis of prostatic : B.

Choe, N. Rose, E. Pontes. Prostatic acid phosphatase (PAP) is the most abundant phosphatase in human prostate tissue/secretions. It is a clinically important protein for its relevance as a biomarker of prostate carcinoma. Prostatic Acid Phosphatase (PAP) is a component of total acid phosphates and is a major constituent in seminal fluid and is also secreted in the urine.

PAP is normally found in serum in very low levels. PAP measurement has found clinical application in the management of prostatic cancer patients. The prostate is a gland of the male reproductive adults, it is about the size of a walnut.

The prostate is located in the pelvis. Within it sits the urethra coming from the bladder which is called the prostatic urethra and which merges with the two ejaculatory ducts. The mean weight of the normal prostate in adult males is about 11 grams, usually ranging between 7 and 16 : Internal pudendal artery, inferior vesical artery.

Limitations: Prostatic Acid Phosphatase (PAP) must not be regarded as an absolute test for malignancy since other factors, including benign prostatic hyperplasia, prostatic infarction, and manipulation of the prostate gland may result in elevated serum PAP concentration.

PAP measurements provide little additional information beyond that. Anti-Transmembrane Prostatic Acid Phosphatase Antibody/TMPAP, clone 3G 1 Product Result. Prostatic acid phosphatase (PAP) is a secretory protein expressed by PCa cells.

We demonstrate that PAP is strongly expressed in PCa bone metastases in 7/7 patients, while prostate-specific. acid phosphatase % of seminal fluid is prostatic fluid and prostatic fluid is acid phosphatase, citric acid, and proteolytic enzymes Which of the following enzyme substrates is the most specific for prostatic acid phosphatase for quantitative endpoint reactions.

within each group. However, more studies are necessary to evaluate the role of prostatic acid phosphatase in the canine prostate and its importance as a diagnostic test for prostate disorders.

Key words: prostate, prostatic acid phosphatase, seminal plasma, serum. Accepted: * via Paulo Donato Castellane, s/n, CEPBrazil; RodoCited by: 4. Prostatic acid phosphatase: (PAP) An enzyme that is normally present only in small amounts in the blood, but that may be found at higher levels in some patients with prostate cancer, especially if the cancer has spread beyond the prostate.

However, blood levels may also be elevated in patients who have certain benign prostate conditions or early stage cancer. Elevation of serum PSA is more a sensitive and specific indicator of prostatic carcinoma than prostatic acid phosphatase (PAP) PSA is raised in over 90% of cases when carcinoma is first detected by comparison to 50% for PAP.

Also called prostatic acid phosphatase. Pap smear listen (pap smeer) A book describing chemicals, drugs, and other substances and how they are used as medicines. It is prepared by a recognized authority. pharmacovigilance listen (FAR-muh. Abstract: The objective of this study was to compare the diagnostic efficacy of three tumor markers (prostatic acid phosphatase [PAP], testosterone [T], and prostate specific antigen [PSA]) for the serodiagnosis of prostate cancer.

Immunoassay reagent test kits were obtained from Diagnostic Automation, Inc. (testosterone, prostatic acid phosphatase) and from Siemens Healthcare Diagnostics.

Acid Phosphatase Test Definition Acid phosphatase is an enzyme found throughout the body, but primarily in the prostate gland. Like all enzymes, it is needed to trigger specific chemical reactions. Acid phosphatase testing is done to diagnose whether prostate cancer has spread to other parts of the body (metastasized), and to check the effectiveness of treatment.

diagnostic for disease in the corresponding organs. Elevated prostatic acid phosphatase levels may indicate the presence of prostate cancer and elevated tartrate-resistant acid phosphatase levels may indicate the bone disease.

The Acid Phosphatase Assay Kit (Colorimetric) is a high sensitivity, simple, direct and HTS-ready. Acid Phosphatase is normally found in many tissues, including liver, red blood cells, bone marrow, and platelets.

The highest levels are found in the prostate gland—the Prostatic Acid Phosphatase (PAP) isoenzyme. Usually (but not always) elevated levels are seen in patients with prostatic cancer that has metastasized beyond the capsule to other parts of the.

Serum and urinary prostatic acid phosphatase (PAP) and prostatic specific antigen (PSA) from 20 dogs were measured. PAP and PSA tests were carried out in authomatized equipment with commercial kits used for humans. Mean PAP serum value was U/l and urinary U/l. Mean serum and urinary PSA were ng/dl and ng/dl, respectively.

Prostatic Acid phosphatase (PAP) is a phosphatase, a type of enzyme, used to free attached phosphate groups from other molecules during digestion. Acid Phosphatase is stored in lysosomes and functions when these fuse with endosomes, which are acidified while they function; therefore, Human Acid Phosphatase has an acid pH optimum below Catalogue Number: ESP Abdominal Sonography Review.

STUDY. Flashcards. Learn. Write. Spell. Test. PLAY. Match. Gravity. Created by. annie_bess. Back of the book purple pages. Terms in this set () All of the following are associated with echinococcal cysts except: A: cyst w/in a cyst presentation Acid phosphatase (Prostatic acid phosphatase "PAP").

physiological functions of prostatic acid phosphatase medicum department of clinical chemistry and haematology faculty of biological and environmental sciences doctoral programme in integrative life science university of helsinki ileana b. quintero dissertationes82/ olaya llano scholae doctoralis ad sanitatem investigandam.

Background: Prostatic Acid Phosphatase/ACPP. Prostatic Acid Phosphatase (ACPP) catalyzes the hydrolysis of a variety of phosphate monoesters, including phosphorylated proteins (1).

The activity optimum of ACPP is in the pH range of 4 - 6, and the activity is inhibited by L(+)-tartrate. specific antigen (PSA) and prostatic acid phosphatase (PAP) are the tumor markers of prostatic carcinoma and have been used for confirming and monitoring prostate cancer (8, 9).

The clinical utility of PSA and PAP for early detection of prostate cancer is hampered by elevation of serum PSA levels in men with prostate benign hyperplasia (10, 11).PACP - Prostatic acid phosphatase.

Looking for abbreviations of PACP? It is Prostatic acid phosphatase. Prostatic acid phosphatase listed as PACP. Prostatic acid phosphatase - How is Prostatic acid phosphatase abbreviated? Prostatic acid phosphatase; prostatic adenocarcinoma; prostatic adenocarcinoma; prostatic adenocarcinoma; prostatic.

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